Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and …
DR Nelson, DC Zeldin, SMG Hoffman… - Pharmacogenetics …, 2004 - journals.lww.com
Objectives Completion of both the mouse and human genome sequences in the private and
public sectors has prompted comparison between the two species at multiple levels. This
review summarizes the cytochrome P450 (CYP) gene superfamily. For the first time, we have
the ability to compare complete sets of CYP genes from two mammals. Use of the mouse as
a model mammal, and as a surrogate for human biology, assumes reasonable similarity
between the two. It is therefore of interest to catalog the genetic similarities and differences …
public sectors has prompted comparison between the two species at multiple levels. This
review summarizes the cytochrome P450 (CYP) gene superfamily. For the first time, we have
the ability to compare complete sets of CYP genes from two mammals. Use of the mouse as
a model mammal, and as a surrogate for human biology, assumes reasonable similarity
between the two. It is therefore of interest to catalog the genetic similarities and differences …