Interaction of genetic and exposure factors in the prevalence of berylliosis
L Richeldi, K Kreiss, MM Mroz, B Zhen… - American journal of …, 1997 - Wiley Online Library
L Richeldi, K Kreiss, MM Mroz, B Zhen, P Tartoni, C Saltini
American journal of industrial medicine, 1997•Wiley Online LibraryPrevalence of berylliosis, a lung disorder driven by the activation of beryllium‐specific T
cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA‐
DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between
marker and exposure in a beryllium‐exposed population in which the prevalence of
berylliosis was associated with machining beryllium. The presence of the marker was
associated with higher prevalence (HLA‐DPB1Glu69‐positive machinists 25%; HLA …
cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA‐
DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between
marker and exposure in a beryllium‐exposed population in which the prevalence of
berylliosis was associated with machining beryllium. The presence of the marker was
associated with higher prevalence (HLA‐DPB1Glu69‐positive machinists 25%; HLA …
Abstract
Prevalence of berylliosis, a lung disorder driven by the activation of beryllium‐specific T cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA‐DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between marker and exposure in a beryllium‐exposed population in which the prevalence of berylliosis was associated with machining beryllium. The presence of the marker was associated with higher prevalence (HLA‐DPB1Glu69‐positive machinists 25%; HLA‐DPB1Glu69‐negative machinists 3.2%, P = 0.05) and predicted berylliosis independent of machining history (odds ratios 11.8 and 10.1). The study shows that in berylliosis the carrier status of a genetic susceptibility factor adds to the effect of process‐related risk factors. Am. J. Ind. Med. 32:337–340, 1997. © 1997 Wiley‐Liss, Inc.
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