Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: characterization and expression in cultured cells
PJ Winwood, D Schuppan, JP Iredale, CA Kawser… - Hepatology, 1995 - Elsevier
Release of 92-kd type IV collagenase/gelatinase, also known as gelatinase B, by
inflammatory and tumor cells is increasingly recognized and is believed to facilitate cellular
migration across basement membranes. It has been implicated in the pathogenesis of many
diseases, but little is known of its cellular origin (s) and function in liver. In this study we have
demonstrated synthesis and release of gelatinase B by human and rat Kupffer cells in
primary culture. Northern analysis of RNA extracted from Kupffer cells stimulated with …
inflammatory and tumor cells is increasingly recognized and is believed to facilitate cellular
migration across basement membranes. It has been implicated in the pathogenesis of many
diseases, but little is known of its cellular origin (s) and function in liver. In this study we have
demonstrated synthesis and release of gelatinase B by human and rat Kupffer cells in
primary culture. Northern analysis of RNA extracted from Kupffer cells stimulated with …
