Initial clinical evaluation of gadolinium DTPA for contrast-enhanced magnetic resonance imaging
VM Runge, W Schoerner, HP Niendorf… - Magnetic resonance …, 1985 - Elsevier
Gadolinium DTPA was evaluated as an intravenous contrast agent for magnetic resonance
imaging in 15 patients with primary or secondary intracranial neoplastic disease. T 1 and T 2
weighted images were obtained prior to contrast administration. T 1 weighted spin echo 35
800 (TE TR) images were utilized to detect enhancement. The increase in signal intensity
observed, identifying areas of breakdown of the blood-brain barrier (BBB), was similar in
magnitude to the contrast enhancement observed on CT. This permitted differentiation of …
imaging in 15 patients with primary or secondary intracranial neoplastic disease. T 1 and T 2
weighted images were obtained prior to contrast administration. T 1 weighted spin echo 35
800 (TE TR) images were utilized to detect enhancement. The increase in signal intensity
observed, identifying areas of breakdown of the blood-brain barrier (BBB), was similar in
magnitude to the contrast enhancement observed on CT. This permitted differentiation of …