Neonatal microscopic polyangiitis secondary to transfer of maternal myeloperoxidase–antineutrophil cytoplasmic antibody resulting in neonatal pulmonary …
PJ Bansal, MC Tobin - Annals of Allergy, Asthma & Immunology, 2004 - Elsevier
BACKGROUND: Microscopic polyangiitis is a systemic vasculitis characterized by small
vessel involvement. Studies suggest myeloperoxidase-antineutrophil cytoplasmic antibody
(MPO-ANCA) is involved in its pathogenesis, and the titer may reflect disease activity.
OBJECTIVE: To report a case of transplacental transfer of MPO-ANCA from a mother to a 33-
week gestational age neonate that resulted in neonatal pulmonary hemorrhage and renal
involvement that was successfully treated with high-dose steroid therapy and exchange …
vessel involvement. Studies suggest myeloperoxidase-antineutrophil cytoplasmic antibody
(MPO-ANCA) is involved in its pathogenesis, and the titer may reflect disease activity.
OBJECTIVE: To report a case of transplacental transfer of MPO-ANCA from a mother to a 33-
week gestational age neonate that resulted in neonatal pulmonary hemorrhage and renal
involvement that was successfully treated with high-dose steroid therapy and exchange …
