Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules
CR Zimmermann, SM Johnson, GW Martens… - Infection and …, 1998 - Am Soc Microbiol
CR Zimmermann, SM Johnson, GW Martens, AG White, BL Zimmer, D Pappagianis
Infection and immunity, 1998•Am Soc MicrobiolThe formaldehyde-killed, whole-spherule vaccine, which is protective against lethal
challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a
soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it
was accompanied by adjuvant, protected mice against lethal intranasal and intravenous
challenge with C. immitis.
challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a
soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it
was accompanied by adjuvant, protected mice against lethal intranasal and intravenous
challenge with C. immitis.
Abstract
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals withCoccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge withC. immitis.
American Society for Microbiology