Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features
BACKGROUND: Major depressive disorder is characterized by increased and sustained
emotional reactivity, which has been linked to sustained amygdala activity. It is also
characterized by disruptions in executive control, linked to abnormal dorsolateral prefrontal
cortex (DLPFC) function. These mechanisms have been hypothesized to interact in
depression. This study explored relationships between amygdala and DLPFC activity during
emotional and cognitive information processing in unipolar depression. METHOD: Twenty …
emotional reactivity, which has been linked to sustained amygdala activity. It is also
characterized by disruptions in executive control, linked to abnormal dorsolateral prefrontal
cortex (DLPFC) function. These mechanisms have been hypothesized to interact in
depression. This study explored relationships between amygdala and DLPFC activity during
emotional and cognitive information processing in unipolar depression. METHOD: Twenty …
