Proliferation of CD8+ in culture of human T cells derived from peripheral blood of adult donors and cord blood of newborns
A Brzezińska, A Magalska, E Sikora - Mechanisms of ageing and …, 2003 - Elsevier
As during replicative senescence either in vivo or in vitro, the growing up subpopulation of
CD8+ CD28− cells is observed, we compared replicative senescence of T cells derived from
mononuclear cells of peripheral blood (PBMC) of adults with those from cord blood (CBMC),
not having yet CD8+ CD28− subpopulation. In PHA-stimulated and IL-2-dependent cultures,
T cells from both cord blood and peripheral blood of young adults displayed similar pattern
of replicative senescence characterised by gradual decrease of proliferation capacity …
CD8+ CD28− cells is observed, we compared replicative senescence of T cells derived from
mononuclear cells of peripheral blood (PBMC) of adults with those from cord blood (CBMC),
not having yet CD8+ CD28− subpopulation. In PHA-stimulated and IL-2-dependent cultures,
T cells from both cord blood and peripheral blood of young adults displayed similar pattern
of replicative senescence characterised by gradual decrease of proliferation capacity …