[HTML][HTML] Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death
SB Lee, IH Bae, YS Bae, HD Um - Journal of biological chemistry, 2006 - ASBMB
Although mitochondria and the Nox family of NADPH oxidase are major sources of reactive
oxygen species (ROS) induced by external stimuli, there is limited information on their
functional relationship. This study has shown that serum withdrawal promotes the production
of ROS in human 293T cells by stimulating both the mitochondria and Nox1. An analysis of
their relationship revealed that the mitochondria respond to serum withdrawal within a few
minutes, and the ROS produced by the mitochondria trigger Nox1 action by stimulating …
oxygen species (ROS) induced by external stimuli, there is limited information on their
functional relationship. This study has shown that serum withdrawal promotes the production
of ROS in human 293T cells by stimulating both the mitochondria and Nox1. An analysis of
their relationship revealed that the mitochondria respond to serum withdrawal within a few
minutes, and the ROS produced by the mitochondria trigger Nox1 action by stimulating …