Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties
NV Rao, NG Wehner, BC Marshall, WR Gray… - Journal of Biological …, 1991 - ASBMB
Proteinase 3 (PR-3) is a human polymorphonuclear leukocyte (PMNL) serine proteinase
that degrades elastin in vitro and causes emphysema when administered by tracheal
insufflation to hamsters (Kao, RC, Wehner, NG, Skubitz, KM, Gray, BH, and Hoidal, JR
(1988) J. Clin. Invest. 82, 1963-1973). We have determined the primary structure of several
PR-3 peptides and have analyzed catalytic properties of the enzyme. The enzyme has
considerable amino acid sequence homology with two other well characterized PMNL …
that degrades elastin in vitro and causes emphysema when administered by tracheal
insufflation to hamsters (Kao, RC, Wehner, NG, Skubitz, KM, Gray, BH, and Hoidal, JR
(1988) J. Clin. Invest. 82, 1963-1973). We have determined the primary structure of several
PR-3 peptides and have analyzed catalytic properties of the enzyme. The enzyme has
considerable amino acid sequence homology with two other well characterized PMNL …