The role of TGFβ1 in initiating hepatic stellate cell activation in vivo
C Hellerbrand, B Stefanovic, F Giordano… - Journal of …, 1999 - Elsevier
Background/Aims: The activation of hepatic stellate cells is a key initiating event in hepatic
fibrogenesis. Although TGFβ1 is a potent inducer of collagen α1 (I) expression in vitro and
elevated levels of TGFβ1 are found in patients and experimental animals with hepatic
fibrosis and cirrhosis, the role of increased TGFβ1 in the initiation of hepatic stellate cell
activation in vivo is unknown. We used two experimental approaches to study this
relationship: 1) Induction of an acute liver injury with carbon tetrachloride (CCl4) in normal …
fibrogenesis. Although TGFβ1 is a potent inducer of collagen α1 (I) expression in vitro and
elevated levels of TGFβ1 are found in patients and experimental animals with hepatic
fibrosis and cirrhosis, the role of increased TGFβ1 in the initiation of hepatic stellate cell
activation in vivo is unknown. We used two experimental approaches to study this
relationship: 1) Induction of an acute liver injury with carbon tetrachloride (CCl4) in normal …