[HTML][HTML] Monocyte recruitment by HLA IgG-activated endothelium: the relationship between IgG subclass and FcγRIIa polymorphisms
NM Valenzuela, KR Trinh, A Mulder… - American journal of …, 2015 - Elsevier
It is currently unclear which donor specific HLA antibodies confer the highest risk of antibody-
mediated rejection (AMR) and allograft loss. In this study, we hypothesized that two distinct
features (HLA IgG subclass and Fcγ receptor [FcγR] polymorphisms) which vary from patient
to patient, influence the process of monocyte trafficking to and macrophage accumulation in
the allograft during AMR in an interrelated fashion. Here, we investigated the contribution of
human IgG subclass and FcγR polymorphisms in monocyte recruitment in vitro by primary …
mediated rejection (AMR) and allograft loss. In this study, we hypothesized that two distinct
features (HLA IgG subclass and Fcγ receptor [FcγR] polymorphisms) which vary from patient
to patient, influence the process of monocyte trafficking to and macrophage accumulation in
the allograft during AMR in an interrelated fashion. Here, we investigated the contribution of
human IgG subclass and FcγR polymorphisms in monocyte recruitment in vitro by primary …