[HTML][HTML] Graft-infiltrating macrophages adopt an M2 phenotype and are inhibited by purinergic receptor P2X7 antagonist in chronic rejection
C Wu, Y Zhao, X Xiao, Y Fan, M Kloc, W Liu… - American Journal of …, 2016 - Elsevier
Macrophages exhibit diverse phenotypes and functions; they are also a major cell type
infiltrating chronically rejected allografts. The exact phenotypes and roles of macrophages in
chronic graft loss remain poorly defined. In the present study, we used a mouse heart
transplant model to examine macrophages in chronic allograft rejection. We found that
treatment of C57BL/6 mice with CTLA4 immunoglobulin fusion protein (CTLA4-Ig) prevented
acute rejection of a Balb/c heart allograft but allowed chronic rejection to develop over time …
infiltrating chronically rejected allografts. The exact phenotypes and roles of macrophages in
chronic graft loss remain poorly defined. In the present study, we used a mouse heart
transplant model to examine macrophages in chronic allograft rejection. We found that
treatment of C57BL/6 mice with CTLA4 immunoglobulin fusion protein (CTLA4-Ig) prevented
acute rejection of a Balb/c heart allograft but allowed chronic rejection to develop over time …