Attenuation of cardiac allograft vasculopathy by sirolimus: Relationship to time interval after heart transplantation
Y Matsuo, A Cassar, S Yoshino, AJ Flammer… - The Journal of Heart and …, 2013 - Elsevier
Background The aim of the study was to assess temporal changes in plaque size and
components after heart transplantation (HTx), and to evaluate the differences in treatment
effects on plaque progression between sirolimus and calcineurin inhibitors (CNIs). Methods
The study comprised 146 HTx recipients who were converted from CNIs to sirolimus as
primary immunosuppressant (sirolimus group, n= 61) and those who were maintained on
CNIs (CNI group, n= 85). A retrospective compositional analysis of serial virtual histology …
components after heart transplantation (HTx), and to evaluate the differences in treatment
effects on plaque progression between sirolimus and calcineurin inhibitors (CNIs). Methods
The study comprised 146 HTx recipients who were converted from CNIs to sirolimus as
primary immunosuppressant (sirolimus group, n= 61) and those who were maintained on
CNIs (CNI group, n= 85). A retrospective compositional analysis of serial virtual histology …