[HTML][HTML] Antibody-mediated rejection in lung transplantation: clinical outcomes and donor-specific antibody characteristics
A Roux, IB Le Lan, S Holifanjaniaina… - American Journal of …, 2016 - Elsevier
In the context of lung transplant (LT), because of diagnostic difficulties, antibody-mediated
rejection (AMR) remains a matter of debate. We retrospectively analyzed an LT cohort at
Foch Hospital to demonstrate the impact of AMR on LT prognosis. AMR diagnosis requires
association of clinical symptoms, donor-specific antibodies (DSAs), and C4d+ staining
and/or histological patterns consistent with AMR. Prospective categorization split patients
into four groups:(i) DSA positive, AMR positive (DSA pos AMR pos);(ii) DSA positive, AMR …
rejection (AMR) remains a matter of debate. We retrospectively analyzed an LT cohort at
Foch Hospital to demonstrate the impact of AMR on LT prognosis. AMR diagnosis requires
association of clinical symptoms, donor-specific antibodies (DSAs), and C4d+ staining
and/or histological patterns consistent with AMR. Prospective categorization split patients
into four groups:(i) DSA positive, AMR positive (DSA pos AMR pos);(ii) DSA positive, AMR …