Evolutionary medicine: from dwarf model systems to healthy centenarians?
VD Longo, CE Finch - Science, 2003 - science.org
VD Longo, CE Finch
Science, 2003•science.orgRestriction of the number of calories consumed extends longevity in many organisms. In
rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth
factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation
without irreversible side effects. In organisms ranging from yeast to mice, mutations in
glucose or IGF-I–like signaling pathways extend life-span but also cause glycogen or fat
accumulation and dwarfism. This information suggests a new category of drugs that could …
rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth
factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation
without irreversible side effects. In organisms ranging from yeast to mice, mutations in
glucose or IGF-I–like signaling pathways extend life-span but also cause glycogen or fat
accumulation and dwarfism. This information suggests a new category of drugs that could …
Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I–like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.
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