[HTML][HTML] Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly
DB Melville, S Studer, R Schekman - Journal of Biological Chemistry, 2020 - ASBMB
Vesicles that are coated by coat protein complex II (COPII) are the primary mediators of
vesicular traffic from the endoplasmic reticulum to the Golgi apparatus. Secretion-associated
Ras-related GTPase 1 (SAR1) is a small GTPase that is part of COPII and, upon GTP
binding, recruits the other COPII proteins to the endoplasmic reticulum membrane. Mammals
have two SAR1 paralogs that genetic data suggest may have distinct physiological roles, eg
in lipoprotein secretion in the case of SAR1B. Here we identified two amino acid clusters that …
vesicular traffic from the endoplasmic reticulum to the Golgi apparatus. Secretion-associated
Ras-related GTPase 1 (SAR1) is a small GTPase that is part of COPII and, upon GTP
binding, recruits the other COPII proteins to the endoplasmic reticulum membrane. Mammals
have two SAR1 paralogs that genetic data suggest may have distinct physiological roles, eg
in lipoprotein secretion in the case of SAR1B. Here we identified two amino acid clusters that …
