Radiotherapy, lymphopenia, and host immune capacity in glioblastoma: a potentially actionable toxicity associated with reduced efficacy of radiotherapy
L Kleinberg, L Sloan, S Grossman, M Lim - Neurosurgery, 2019 - journals.lww.com
Radiotherapy is cytotoxic to tumor cells and is therefore a critical component of therapy for
many malignancies, including glioblastoma (GBM). We now appreciate the value of the
immunomodulatory effects of radiation that may be important to overall therapeutic success
in some patients with this primary brain tumor. Although potentially beneficial immune-
stimulating properties of radiotherapy treatment have been the focus of recent study, this
modality is actually at the same time associated with the depletion of lymphocytes, which are …
many malignancies, including glioblastoma (GBM). We now appreciate the value of the
immunomodulatory effects of radiation that may be important to overall therapeutic success
in some patients with this primary brain tumor. Although potentially beneficial immune-
stimulating properties of radiotherapy treatment have been the focus of recent study, this
modality is actually at the same time associated with the depletion of lymphocytes, which are …
