[HTML][HTML] Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

EP Mottillo, P Balasubramanian, YH Lee, C Weng… - Journal of lipid …, 2014 - ASBMB
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both
brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent and
UCP1-independent processes. The present work examined de novo lipogenesis (DNL) and
TG/glycerol dynamics in classic brown, subcutaneous" beige," and classic white adipose
tissues during sustained β3-AR activation by CL 316,243 (CL) and also addressed the
contribution of TG hydrolysis to these dynamics. CL treatment for 7 days dramatically …