[HTML][HTML] Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans
TY Lim, E Perpiñán, MC Londoño, R Miquel, P Ruiz… - Journal of …, 2023 - Elsevier
Background & Aims CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) are essential to
maintain immunological tolerance and have been shown to promote liver allograft tolerance
in both rodents and humans. Low-dose IL-2 (LDIL-2) can expand human endogenous
circulating Tregs in vivo, but its role in suppressing antigen-specific responses and
promoting Treg trafficking to the sites of inflammation is unknown. Likewise, whether LDIL-2
facilitates the induction of allograft tolerance has not been investigated in humans. Methods …
maintain immunological tolerance and have been shown to promote liver allograft tolerance
in both rodents and humans. Low-dose IL-2 (LDIL-2) can expand human endogenous
circulating Tregs in vivo, but its role in suppressing antigen-specific responses and
promoting Treg trafficking to the sites of inflammation is unknown. Likewise, whether LDIL-2
facilitates the induction of allograft tolerance has not been investigated in humans. Methods …