[HTML][HTML] Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C–NMDA receptors in paclitaxel-induced neuropathic pain
Chemotherapeutic drugs such as paclitaxel cause painful peripheral neuropathy in many
cancer patients and survivors. Although NMDA receptors (NMDARs) at primary afferent
terminals are known to be critically involved in chemotherapy-induced chronic pain, the
upstream signaling mechanism that leads to presynaptic NMDAR activation is unclear.
Group I metabotropic glutamate receptors (mGluRs) play a role in synaptic plasticity and
NMDAR regulation. Here we report that the Group I mGluR agonist (S)-3, 5 …
cancer patients and survivors. Although NMDA receptors (NMDARs) at primary afferent
terminals are known to be critically involved in chemotherapy-induced chronic pain, the
upstream signaling mechanism that leads to presynaptic NMDAR activation is unclear.
Group I metabotropic glutamate receptors (mGluRs) play a role in synaptic plasticity and
NMDAR regulation. Here we report that the Group I mGluR agonist (S)-3, 5 …