Background & Aims Myc is involved in cell growth, proliferation, apoptosis, energy
metabolism, and differentiation. Whether it is essential for hepatocellular proliferation and
carcinogenesis is unclear due to a lack of an efficient hepatocyte-specific Myc disruption
model. This study used a novel genetic model to investigate the involvement of Myc in
hepatocellular proliferation and hepatocarcinogenesis in mice. Methods Temporal
hepatocyte-specific Myc disruption was achieved by use of the tamoxifen-inducible Cre-ER …