[HTML][HTML] Developing aptamers into therapeutics
RR White, BA Sullenger… - The Journal of clinical …, 2000 - Am Soc Clin Investig
RR White, BA Sullenger, CP Rusconi
The Journal of clinical investigation, 2000•Am Soc Clin InvestigDecoy RNA corresponding to the TAR RNA sequence competes with the viral encoded
sequence for binding of tat protein. By sequestering the tat protein from the real TAR RNA
sequence present in the HIV viral RNA, the decoy RNA can inhibit HIV RNA transcription
and thus reduce viral replication.
sequence for binding of tat protein. By sequestering the tat protein from the real TAR RNA
sequence present in the HIV viral RNA, the decoy RNA can inhibit HIV RNA transcription
and thus reduce viral replication.
Decoy RNA corresponding to the TAR RNA sequence competes with the viral encoded sequence for binding of tat protein. By sequestering the tat protein from the real TAR RNA sequence present in the HIV viral RNA, the decoy RNA can inhibit HIV RNA transcription and thus reduce viral replication.
The Journal of Clinical Investigation