Nucleic acid-sensing TLRs as modifiers of autoimmunity
JA Deane, S Bolland - The Journal of Immunology, 2006 - journals.aai.org
JA Deane, S Bolland
The Journal of Immunology, 2006•journals.aai.orgThe immune system requires precise regulation of activating and inhibitory signals so that it
can mount effective responses against pathogens while ensuring tolerance to self-
components. Some of the most potent activation signals are triggered by innate immune
molecules, particularly those in the TLR family. Recent studies have shown that engagement
of TLRs plays a significant role in both innate and adaptive immunity. This review focuses on
the ways that TLR function might contribute to the etiology of lupus-like syndromes in the …
can mount effective responses against pathogens while ensuring tolerance to self-
components. Some of the most potent activation signals are triggered by innate immune
molecules, particularly those in the TLR family. Recent studies have shown that engagement
of TLRs plays a significant role in both innate and adaptive immunity. This review focuses on
the ways that TLR function might contribute to the etiology of lupus-like syndromes in the …
Abstract
The immune system requires precise regulation of activating and inhibitory signals so that it can mount effective responses against pathogens while ensuring tolerance to self-components. Some of the most potent activation signals are triggered by innate immune molecules, particularly those in the TLR family. Recent studies have shown that engagement of TLRs plays a significant role in both innate and adaptive immunity. This review focuses on the ways that TLR function might contribute to the etiology of lupus-like syndromes in the context of an autoimmune-prone environment. By considering the sources, localization, and expression of both nucleic acids and the molecules that bind them, we discuss several ways that innate immunity can play a role in the development of systemic autoimmunity.
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